RNA-Seq Analysis of Gene Expression, Viral Pathogen, and B-Cell/T-Cell Receptor Signatures in Complex Chronic Disease.
Title | RNA-Seq Analysis of Gene Expression, Viral Pathogen, and B-Cell/T-Cell Receptor Signatures in Complex Chronic Disease. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Bouquet J, Gardy JL, Brown S, Pfeil J, Miller RR, Morshed M, Avina-Zubieta A, Shojania K, McCabe M, Parker S, Uyaguari M, Federman S, Tang P, Steiner T, Otterstater M |
Journal | Clin Infect Dis. |
Volume | 64 |
Start Page | 476 |
Issue | 4 |
Date Published | 02/2017 |
Keywords | adcls, b-cell, bfs, chronic, complex, disease, lyme, pathogen, receptor, t-cell, virus |
Abstract | Here, we performed blinded RNA-seq analysis of whole blood collected from 25 adults diagnosed with CFS and 13 ADCLS patients, comparing these cases to 25 matched controls and 11 patients with well-controlled systemic lupus erythematosus (SLE). Samples were collected at patient enrollment and not during acute symptom flares. RNA-seq data were used to study host gene expression, B-cell/T-cell receptor profiles (BCR/TCR), and potential viral infections. |
URL | https://www.ncbi.nlm.nih.gov/pubmed/28172519 |