|Title||Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia.|
|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Lee WY, Sanz MJ, Wong CH, Hardy PO, Salman-Dilgimen A, Moriarty TJ, Chaconas G, Marques A, Krawetz R, Mody CH, Kubes P|
|Journal||Proc Natl Acad Sci U S A|
|Keywords||granzyme B, joint iNKT cells, Lyme arthritis|
Successful penetrance of B. burgdorferi out of the vasculature and into the joint tissue was met by a lethal attack by extravascular iNKT cells through a granzyme-dependent pathway, an observation also made in vitro for iNKT cells from joint but not liver or spleen. These results suggest a novel, critical extravascular iNKT cell immune surveillance in joints that functions as a cytotoxic barrier and explains a large increase in pathogen burden of B. burgdorferi in the joint of iNKT cell-deficient mice, and perhaps the greater susceptibility of humans to this pathogen because of fewer iNKT cells in human joints.