Intravital Imaging of Vascular Transmigration by the Lyme Spirochete: Requirement for the Integrin Binding Residues of the B. burgdorferi P66 Protein

TitleIntravital Imaging of Vascular Transmigration by the Lyme Spirochete: Requirement for the Integrin Binding Residues of the B. burgdorferi P66 Protein
Publication TypeJournal Article
Year of Publication2015
AuthorsKumar D, Ristow LC, Shi M, Mukherjee P, Caine JA, Lee WY, Kubes P, Coburn J, Chaconas G
JournalPLos Pathog
Volume11
Issue12
Start Pagee1005333
Date Published12/2015
Abstract

Although integrin-binding proteins with diverse functions are encoded by a variety of bacterial pathogens, P66 is the first to have a documented and direct role in vascular transmigration. The emerging picture of vascular escape by the Lyme spirochete shows similarities, but distinct differences from leukocyte transmigration.

URLhttp://www.ncbi.nlm.nih.gov/pubmed/26684456
DOI10.1371/journal.ppat.1005333