Evidence for Host-Genotype Associations of Borrelia burgdorferi Sensu Stricto

TitleEvidence for Host-Genotype Associations of Borrelia burgdorferi Sensu Stricto
Publication TypeJournal Article
Year of Publication2016
AuthorsMechai S, Margos G, Feil EJ, Barairo N, Lindsay LR, Michel P, Ogden NH
JournalPLoS One
Volume11
Start Pagee0149345
Issue2
Date Published02/2016
Abstract

Different genotypes of the agent of Lyme disease in North America, Borrelia burgdorferi sensu stricto, show varying degrees of pathogenicity in humans.Correspondence analysis and generalized linear mixed effect models revealed significant associations between B. burgdorferi genotypes and host species (in particular chipmunks, and white-footed mice and deer mice), supporting the hypotheses that host adaptation contributes to the phylogenetic structure and possibly the observed variation in pathogenicity in humans.

URLhttp://www.ncbi.nlm.nih.gov/pubmed/26901761
DOI10.1371/journal.pone.0149345