Antigenic variation in the Lyme spirochete: detailed functional assessment of recombinational switching at vlsE in the JD1 strain of Borrelia burgdorferi.

TitleAntigenic variation in the Lyme spirochete: detailed functional assessment of recombinational switching at vlsE in the JD1 strain of Borrelia burgdorferi.
Publication TypeJournal Article
Year of Publication2018
AuthorsVerhey TB, Castellanos M, Chaconas G
JournalMol Microbiol.
Date Published12/2018
Keywordsantigenic variation, borrelia burgdorferi, JD1, Lyme disease, vlsE
Abstract

We show that antigenic variation in B31 and JD1 is highly similar, despite the lack of 17 bp direct repeats in JD1, a somewhat different arrangement of the silent cassettes, divergent inverted repeat sequences, and general divergence in the vls sequences. We also present data that strongly suggests that dimerization is required for in vivo functionality of VlsE.

URLhttps://www.ncbi.nlm.nih.gov/pubmed/30580501